AARON ARKIN, PH.D., M.D., F.A.C.P.; HANS POPPER, M.S., M.D.; FRED A. GOLDBERG, M.D.
Whereas there are well established methods of determining definite kidney insufficiency, the detection of low grade kidney damage by simple methods is still a problem. The purpose of this study is to show the value of plasma creatinine determination by newer methods, in the solution of this question.
In kidney damage the glomerular function is usually the first to be impaired as indicated by reduction of glomerular filtration. The original method of Rehberg1 who used the exogenous creatinine clearance as a measure of glomerular filtration has been discarded, since in man creatinine is secreted when the blood level is artificially
ARKIN A, POPPER H, GOLDBERG FA. PLASMA CREATININE DETERMINATION AS A TEST OF LOW GRADE KIDNEY DAMAGE(PLASMA CREATININE DETERMINATION AS A TEST OF LOW GRADE KIDNEY DAMAGE*). Ann Intern Med. 1941;15:700–707. doi: 10.7326/0003-4819-15-4-700
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Published: Ann Intern Med. 1941;15(4):700-707.
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