J. MARSHALL NEELY, M.D., F.A.C.P.
Congenital idiopathic cardiac hypertrophy is a term which has been used to designate cardiac enlargement occurring in infants and young children with no demonstrable etiology. As more attention is given to this group of cases it becomes apparent that those which are truly idiopathic constitute a small minority. S. Van Creveld2 and others have shown that many cases of cardiac enlargement thought to be idiopathic are Von Gierke's disease, or "hepatomegalia glycogenica," in which there is glycogen infiltration of the heart, liver, and kidneys. Cardiac enlargement has also been shown to occur in the primary anemias of childhood, particularly in
NEELY JM. IDIOPATHIC CARDIAC ENLARGEMENT OCCURRING IN INFANTS AND CHILDREN1. Ann Intern Med. ;15:727–742. doi: 10.7326/0003-4819-15-4-727
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Published: Ann Intern Med. 1941;15(4):727-742.
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