WILLIAM C. STADIE, M.D.
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The enormous amount of research on the abnormal metabolic processes of diabetes mellitus since the time of v. Mehring and Minkowski has failed to bring unity of conviction to students of the disease. We find today, as in earlier times, two opposing hypotheses still striving for supremacy. These two hypotheses may be briefly stated as follows:
I. The under-utilization hypothesis states that the major defect in the intermediary metabolism of the diabetic is the inability of the tissues to oxidize sufficient carbohydrate for normal metabolic needs. In consequence, ingested carbohydrate and that derived from protein is excreted.
II. The over-production
STADIE WC. FAT METABOLISM IN DIABETES MELLITUS1. Ann Intern Med. ;15:783–797. doi: 10.7326/0003-4819-15-5-783
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Published: Ann Intern Med. 1941;15(5):783-797.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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