MAHLON H. DELP, M.D.; C. J. WEBER, M.D.
With the advent of arsenic as a spirochetocide, the physician found that one of his great problems in handling the syphilitic patient was that of avoiding, if possible, the toxic manifestations of this therapeutic agent, or of treating them if they appeared. Numerous improvements in arsenical preparations and improvements in the technic of their administration have not yet eliminated these problems. Toxic manifestations take many forms—from the milder gastrointestinal disturbances to the severe hemorrhagic encephalitis—with the intermediate complications of hepatitis, purpura, and arsenical dermatitis occurring all too frequently. In a large antisyphilitic clinic, constant and individual attention must be given
DELP MH, WEBER CJ. ARSENICAL SENSITIVITY AND VITAMIN C1. Ann Intern Med. ;15:890–898. doi: 10.7326/0003-4819-15-5-890
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Published: Ann Intern Med. 1941;15(5):890-898.
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