ISADORE ROTHSTEIN, M.D.; SIDNEY COHN, M.D.
Soon after the introduction of sulfanilamide into this country reports of various toxic manifestations following its use began to appear, among them reports of acute hemolytic anemia. Acute hemolytic anemia due to sulfanilamide administration was first described by Harvey and Janeway1 in 1937 and since then has been noted by many other observers. In a large series of cases the incidence of this complication following sulfanilamide has been estimated as approximately 2.5 per cent of all adults and 8.5 per cent of all children receiving the drug.2 Later studies have revealed an incidence of 1.8 per cent in all patients.3
ROTHSTEIN I, COHN S. ACUTE HEMOLYTIC ANEMIA, AUTOAGGLUTINATION, TOXIC HEPATITIS AND RENAL DAMAGE FOLLOWING SULFATHIAZOLE THERAPY; CASE REPORT1. Ann Intern Med. 1942;16:152–162. doi: 10.7326/0003-4819-16-1-152
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Published: Ann Intern Med. 1942;16(1):152-162.
Emergency Medicine, Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease, Nephrology.
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