J. E. H.
It is well known that with skeletal immobilization there occurs bone rarefaction. It is also well known that a considerable portion of the lime salts exported from the body in this process are handled by the kidneys. The excess excretion of calcium in the urine, or hypercalciuria, is presumably the reason for the frequency of urinary tract stones in patients with healing fractures, an association which has been observed for many years.
That hypercalcemia can be a direct result of the rapid mobilization of lime salts during the development of atrophy of disuse has only very recently been suggested. Two
J. E. H.. HYPERCALCEMIA AND RENAL INJURY. Ann Intern Med. 1942;16:176–178. doi: 10.7326/0003-4819-16-1-176
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Published: Ann Intern Med. 1942;16(1):176-178.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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