LAWRENCE S. SIEGEL, M.D.; LEON ROSOVE, M.D.; ALBERT G. BOWER, M.D., F.A.C.P.
Prior to the use of sulfanilamide in the treatment of erysipelas, there was no effective mode of therapy. Early in 1935 Myer-Heine and Huguenin1 treated 150 cases with the dye sulphamido-chrysoidin, reporting rapid and constant results as regard temperature and local phenomena. Kramer2 in April 1936 reported 32 cases treated with prontosil, and expressed the opinion that it was the most effective drug used against the disease. Breen and Taylor3 in June 1937 reported a series of 46 consecutive cases treated with prontosil in which the temperature fell to normal or below in 48 hours, and no spread or relapse
SIEGEL LS, ROSOVE L, BOWER AG. SULFANILAMIDE IN THE TREATMENT OF ERYSIPELAS1. Ann Intern Med. ;16:262–268. doi: 10.7326/0003-4819-16-2-262
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Published: Ann Intern Med. 1942;16(2):262-268.
Infectious Disease, Streptococcal Infections.
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