LEO WAITZKIN; RICHARD H. SMITH; WALTER B. MARTIN, F.A.C.P.
The sulfonamides and heparin have been among the most recent forms of therapy in subacute bacterial endocarditis. Concerning the value of the sulfonamides there are widely divergent opinions. Some are to the effect that they are of doubtful or no value, others that recoveries may be definitely ascribed to their usage.1, 2, 3, 4, 5, 6, 16 Concerning heparin in conjunction with sulfapyridine, no optimistic conclusions have been expressed since the sanguine preliminary report by Kelson and White.7
A consideration of factors involved in subacute bacterial endocarditis clarifies the reasons advanced for the employment of heparin and sulfonamide compounds, and
WAITZKIN L, SMITH RH, MARTIN WB. SULFONAMIDES AND HEPARIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS1. Ann Intern Med. ;16:356–360. doi: 10.7326/0003-4819-16-2-356
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Published: Ann Intern Med. 1942;16(2):356-360.
Cardiology, Endocarditis, Infectious Disease, Streptococcal Infections.
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