HAROLD L. RAKOV, M.D.
The ectopic rhythms which occur following an acute myocardial infarction are usually transitory and benign. Sometimes ventricular tachycardia is an exception to this rule. This arrhythmia has been produced experimentally by ligation of the coronary arteries, and Levine1 observed it frequently in acute myocardial infarction. Master,2 on the other hand, found that it occurred in coronary occlusion infrequently except following the use of digitalis. The ischemic area is hyperirritable and a source of this idioventricular rhythm. Epinephrine enhances this irritability not only by increasing the myocardial ischemia at a time when a greater blood supply is needed,3 but also
RAKOV HL. VENTRICULAR FIBRILLATION IN ACUTE CORONARY ARTERY THROMBOSIS DURING THE INTRAVENOUS ADMINISTRATION OF QUINIDINE SULPHATE; REPORT OF A FATAL CASE1. Ann Intern Med. ;16:571–576. doi: 10.7326/0003-4819-16-3-571
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Published: Ann Intern Med. 1942;16(3):571-576.
Cardiology, Rhythm Disorders and Devices.
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