The remarkably successful results obtained clinically in the treatment of pneumococcus pneumonia with the sulfonamide drugs have stimulated interest in the mechanism of their action, and in their influence on the development of immunity to this organism.
Earlier studies by Whitby1 and others of the effect of sulfapyridine on pneumococci in vitro showed that in concentrations such as can be obtained in the animal body, it exerts a bacteriostatic effect, inhibiting the growth of the organisms without actually destroying them. In higher concentrations an actual bactericidal action may be manifested. This action is not exerted immediately. In a freshly inoculated
C. P. THE RELATION OF SPECIFIC IMMUNITY TO RECOVERY FROM PNEUMOCOCCUS PNEUMONIA TREATED WITH THE SULFONAMIDES. Ann Intern Med. ;16:577–580. doi: 10.7326/0003-4819-16-3-577
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Published: Ann Intern Med. 1942;16(3):577-580.
Infectious Disease, Pneumonia, Pulmonary/Critical Care, Streptococcal Infections.
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