WINDSOR C. CUTTING, M.D.; ERNEST H. SULTAN, A.B.
The increasing importance of sulfathiazole in the treatment of bacterial infections makes it desirable to elucidate any differences from the more familiar sulfanilamide, particularly concerning distribution in the body. Thus it has been thought that sulfathiazole penetrated into the spinal fluid less readily than sulfanilamide, and was also less readily absorbed from the rectum. This report presents results on these aspects of the sulfonamides in animals and patients.
Sadusk and coauthors,1 in 1940, claimed that spinal fluid concentrations of sulfathiazole, from 0 to 25 per cent of the simultaneous blood values, occurred after four hours of administration
CUTTING WC, SULTAN EH. SULFONAMIDES: PASSAGE INTO SPINAL FLUID AND RECTAL ABSORPTION1. Ann Intern Med. ;16:708–715. doi: 10.7326/0003-4819-16-4-708
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Published: Ann Intern Med. 1942;16(4):708-715.
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