HARRY GROSS, M.D.; MARTA SANDBERG, PH.D.
The rôle of creatine in muscle metabolism has been well established. All voluntary muscles of vertebrates are rich in creatine, whereas smooth muscle contains relatively little. Muscle efficiency stands in a definite relationship to the amount of creatine present.
Numerous investigators have determined the creatine content of heart and skeletal muscle. As early as 1913 Myers and Fine1 reported on muscle
creatine under normal conditions. They established the fact that urinary creatinine and muscle creatine are interdependent in a given species. Denis,2 in 1916, studied the creatine content of normal psoas muscle.
Constabel,3 in 1921, was the first to determine
GROSS H, SANDBERG M. THE CONCENTRATION OF CREATINE IN HEART, DIAPHRAGM, AND SKELETAL MUSCLE IN UREMIA1. Ann Intern Med. ;16:737–749. doi: 10.7326/0003-4819-16-4-737
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Published: Ann Intern Med. 1942;16(4):737-749.
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