ELAINE P. RALLI, M.D.; HAROLD BRANDALEONE, M.D.; HARRY D. FEIN, M.D.
In a previous study1 we reported observations on 20 patients with diabetes mellitus who were followed for periods while on regular insulin and who were then transferred to protamine zinc insulin and observed for periods of eight to 14 months. In this group of patients it was found that four never reacted favorably to protamine zinc insulin, and that after eight months five patients had to be returned to regular insulin alone because of the tendency for the occurrence of severe insulin shock or uncontrolled glycosuria. Of the remaining 11 patients of the group eight required both regular and protamine
RALLI EP, BRANDALEONE H, FEIN HD. OBSERVATIONS ON THE COMPARABLE EFFECTS OF PROTAMINE ZINC AND REGULAR INSULIN IN DIABETIC PATIENTS FOLLOWED OVER A PERIOD OF YEARS1. Ann Intern Med. ;16:750–761. doi: 10.7326/0003-4819-16-4-750
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Published: Ann Intern Med. 1942;16(4):750-761.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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