HARRY SHAY, M.D.; J. GERSHON-COHEN, M.D., D.SC. (MED.); SAMUEL S. FELS, LL.D.
The symptomatology of duodenal ulcer is due in large part to the disordered gastric physiology. It is also true that if an adequate explanation for the disordered physiology were available, therapy could possibly be directed into more physiological channels than is now the practice. The disordered gastric function in duodenal ulcer, as is well known, takes the form of both motor and secretory changes. In uncomplicated cases, the abnormal motor phenomena are hyperperistalsis, hypertonicity, and hypermotility. The secretory abnormality is hypersecretion. These abnormal gastric findings have long been recognized, but no suitable explanation for their existence has as yet been
SHAY H, GERSHON-COHEN J, FELS SS. A THEORY EXPLAINING THE LOCAL MECHANISM FOR GASTRIC MOTOR AND SECRETORY CONTROL AND THE ALTERATION OF THESE FUNCTIONS IN UNCOMPLICATED DUODENAL ULCER1. Ann Intern Med. ;16:772–781. doi: 10.7326/0003-4819-16-4-772
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Published: Ann Intern Med. 1942;16(4):772-781.
Gastroenterology/Hepatology, Peptic Disease, Peptic Ulcer.
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