EDWARD TOLSTOI, M.D.; THOMAS P. ALMY, M.D.; VINCENT TOSCANI, B.S.
Two years ago, we presented our criteria for the satisfactory treatment of diabetes mellitus with protamine insulin. Briefly, we preferred (a) one injection a day, and (b) we were guided by the patient's weight, (c) his freedom from symptoms, (d) his freedom from ketonuria, and (e) the absence of insulin reactions. The experimental and clinical evidence upon which this treatment was based has been published in detail elsewhere.1 It was our experience that the most reliable protection the patient had from the hypoglycemic syndrome was a glycosuria. We, therefore, included among our criteria the desirability of a glycosuria.
TOLSTOI E, ALMY TP, TOSCANI V. TREATMENT OF DIABETES MELLITUS WITH PROTAMINE INSULIN: IS A PERSISTENT GLYCOSURIA HARMFUL? A METABOLIC STUDY OF A SEVERE CASE1. Ann Intern Med. ;16:893–903. doi: 10.7326/0003-4819-16-5-893
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Published: Ann Intern Med. 1942;16(5):893-903.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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