ROBERT C. MANCHESTER, M.S., M.D.
In a private practice which included a large group of patients with chronic complaints an appreciable number gave stories strongly suggestive of chronic brucellosis. Agglutination tests sent to the state laboratory were consistently negative. The problem, then, was the correct recognition of a disease which, in its chronic form, exhibits protean but ill-defined manifestations, and the correlation of these varied clinical aspects.
That brucellosis exists as a chronic, protracted disease, in addition to the acute self-limited form, has been recognized by Hardy,1 Huddleson,2 Evans,3 Calder,4 Cameron and Wells,5 and others.
Evans3 recognized the unreliability of the accepted laboratory procedures for
MANCHESTER RC. THE CLINICAL MANIFESTATIONS AND DIAGNOSIS OF CHRONIC BRUCELLOSIS1. Ann Intern Med. ;16:950–965. doi: 10.7326/0003-4819-16-5-950
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Published: Ann Intern Med. 1942;16(5):950-965.
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