The spleen has long been known to include among its functions an important rôle in the production of the formed elements of the blood and also in their eventual elimination from the circulation. These functions are dependent primarily upon the reticuloendothelial cells in the spleen, and they are shared in varying degree by other organs and tissues which contain such cells. In the normal adult the part which the spleen plays directly in contributing new cells to the circulation is insignificant and is limited probably to the production of a few lymphocytes and monocytes. In certain types of anemia, however,
SOME INDICATIONS AND CONTRAINDICATIONS FOR SPLENECTOMY. Ann Intern Med. ;16:1253–1255. doi: 10.7326/0003-4819-16-6-1253
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Published: Ann Intern Med. 1942;16(6):1253-1255.
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