MORRIS WILBURNE, M.D.; THOMAS A. MCGOLDRICK, M.D.
The literature is replete with reports of the various toxic effects of sulfapyridine. Of principal importance are the effects on the blood, urinary tract, and liver. The occurrence of agranulocytosis was originally reported by Johnston,1 later followed by Coxon and Forbes,2 Barnett et al.,3 Shullenberger,4 and others. Acute hemolytic anemia was noted by Long and associates5 in 0.6 per cent of 297 cases treated with sulfapyridine. The deposition of acetylsulfapyridine calculi in the urinary tract of experimental animals was first reported by Antopol and Robinson,6 and by Gross, Cooper and Lewis,7 and shortly afterward Southworth and Cooke8 described the occurrence
WILBURNE M, MCGOLDRICK TA. PROLONGED ADMINISTRATION OF SULFAPYRIDINE IN SUBACUTE BACTERIAL ENDOCARDITIS; REPORT OF CASE FOLLOWING ADMINISTRATION OF 621 GRAMS1. Ann Intern Med. ;17:333–339. doi: 10.7326/0003-4819-17-2-333
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Published: Ann Intern Med. 1942;17(2):333-339.
Cardiology, Endocarditis, Infectious Disease, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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