LEWIS DEXTER, M.D.
The pressor substance, hypertensin, was demonstrated by Braun-Menendez, Fasciolo, Leloir, and Muñoz1, 2, 3, 4 of this Institute in the renal venous blood of ischemic kidneys and was shown to be identical with the pressor substance produced by the in vitro incubation of renin with blood globulins (hypertensin precursor) and unlike other known pressor substances. They concluded, therefore, that hypertensin is the pressor substance responsible for hypertension due to renal ischemia. Braun-Menendez and his collaborators2, 3, 4, 5 likewise described a substance, hypertensinase, which destroys or inactivates hypertensin. Its distribution in the body, a method of its extraction from tissues,
DEXTER L. THE HYPERTENSINASE CONTENT OF PLASMA OF NORMAL, HYPERTENSIVE AND NEPHRECTOMIZED DOGS1. Ann Intern Med. 1942;17:447–450. doi: 10.7326/0003-4819-17-3-447
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Published: Ann Intern Med. 1942;17(3):447-450.
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