B. A. HOUSSAY, M.D.; L. DEXTER, M.D.
In 1898 Tigerstedt and Bergmann1 discovered a pressor substance in normal kidneys to which they gave the name renin. This substance had a prolonged pressor effect when injected intravenously into animals, successive injections had a diminishing pressor action (tachyphylaxis), and it was not found in organs other than the kidneys. Their findings have been widely confirmed by subsequent investigators. With the development of a method of inducing hypertension experimentally in animals by Goldblatt, Lynch, Hanzal, and Summerville2 and with the resultant evidence that this renal hypertension was apparently due to a humoral mechanism,3, 4 the rôle played by renin in
HOUSSAY BA, DEXTER L. THE SENSITIVITY TO HYPERTENSIN, ADRENALIN AND RENIN OF UNANESTHETIZED NORMAL, ADRENALECTOMIZED, HYPOPHYSECTOMIZED AND NEPHRECTOMIZED DOGS1. Ann Intern Med. ;17:451–460. doi: 10.7326/0003-4819-17-3-451
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Published: Ann Intern Med. 1942;17(3):451-460.
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