B. A. HOUSSAY, M.D.; L. DEXTER, M.D.
In 1898 Tigerstedt and Bergmann1 discovered a pressor substance in normal kidneys to which they gave the name renin. This substance had a prolonged pressor effect when injected intravenously into animals, successive injections had a diminishing pressor action (tachyphylaxis), and it was not found in organs other than the kidneys. Their findings have been widely confirmed by subsequent investigators. With the development of a method of inducing hypertension experimentally in animals by Goldblatt, Lynch, Hanzal, and Summerville2 and with the resultant evidence that this renal hypertension was apparently due to a humoral mechanism,3, 4 the rôle played by renin in
HOUSSAY BA, DEXTER L. THE SENSITIVITY TO HYPERTENSIN, ADRENALIN AND RENIN OF UNANESTHETIZED NORMAL, ADRENALECTOMIZED, HYPOPHYSECTOMIZED AND NEPHRECTOMIZED DOGS(THE SENSITIVITY TO HYPERTENSIN, ADRENALIN AND RENIN OF UNANESTHETIZED NORMAL, ADRENALECTOMIZED, HYPOPHYSECTOMIZED AND NEPHRECTOMIZED DOGS*). Ann Intern Med. 1942;17:451–460. doi: 10.7326/0003-4819-17-3-451
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Published: Ann Intern Med. 1942;17(3):451-460.
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