A. C. WOOFTER, M.D., F.A.C.P.; B. S. PARKS, M.D.
In 1861 Nicolaus Friedreich first described a primary hereditary spinal cord disease which caused progressive ataxia of first the legs and then the arms, but without paralysis of the sphincters or disturbance of the senses. He correctly assigned the major pathologic lesions to the region of the posterior and lateral columns, designating it a chronic degenerative atrophy, but thought it closely related to tabes dorsalis, a belief which was later disproved. Following this several similar cases were reported and later many variations from the usual type were described, such as those in which cerebellar involvement predominated, a form now classed
WOOFTER AC, PARKS BS. FRIEDREICH'S ATAXIA1. Ann Intern Med. 1942;17:744–750. doi: 10.7326/0003-4819-17-4-744
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Published: Ann Intern Med. 1942;17(4):744-750.
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