Immunity to tuberculous infection differs in many ways from that occurring in infections with most of the ordinary pathogenic bacteria. In the laboratory animals which have been most carefully studied and probably in man any notable degree of resistance seems to depend upon the presence of living tubercle bacilli in the body tissues. If a normal rabbit or guinea pig is inoculated locally with a suitable dose of a pathogenic strain, the animals show but little resistance to the infection, the organisms multiply freely and the infection becomes disseminated. If, however, such an injection is made into an animal previously
THE RÔLE OF MONONUCLEAR PHAGOCYTES IN IMMUNITY
TO TUBERCULOSIS. Ann Intern Med. ;17:755–757. doi: 10.7326/0003-4819-17-4-755
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Published: Ann Intern Med. 1942;17(4):755-757.
Infectious Disease, Mycobacterial Infections.
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