ROBERT W. HEINLE; JOSEPH T. WEARN, F.A.C.P.; DAVID R. WEIR; FREDERICK A. ROSE
In previous brief reports,1, 2 the effect in guinea pigs of injection of extracts of urine from patients with leukemia has been described. The results indicated that extracts of urine from patients with chronic myeloid leukemia produced myeloid hyperplasia and metaplasia in the organs of guinea pigs with considerably greater frequency than did extracts of urine from patients with other diseases and from normal people.
Four different methods of extraction were effective in recovering the active material from the urine of patients with chronic myeloid leukemia. These included the original kaolin adsorption, a benzoic acid adsorption, and a chloroform extraction.
HEINLE RW, WEARN JT, WEIR DR, ROSE FA. MYELOID HYPERPLASIA AND METAPLASIA INDUCED BY EXTRACTS OF URINE FROM PATIENTS WITH MYELOGENOUS LEUKEMIA1. Ann Intern Med. 1942;17:902–919. doi: 10.7326/0003-4819-17-6-902
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Published: Ann Intern Med. 1942;17(6):902-919.
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