IRVINE H. PAGE, M.D.; O. M. HELMER, PH.D.; K. G. KOHLSTAEDT, M.D.; G. F. KEMPF, M.D.; A. C. CORCORAN, M.D.; R. D. TAYLOR, M.D.
At this time last year we reported to you the reasons why we believe that certain extracts of normal kidneys contain a substance, or substances, which lowers arterial blood pressure in hypertensive dogs, rats and human beings.1 It was pointed out that one of the most striking effects of these extracts was their ability to reverse the retinal arterial lesions observed during the course of the malignant phase of hypertension. Their administration was also often associated with a rise in the usually depressed renal blood flow.
Difficulties both in the preparation of the extract and in its use were numerous.
PAGE IH, HELMER OM, KOHLSTAEDT KG, KEMPF GF, CORCORAN AC, TAYLOR RD. A PROGRESS REPORT OF INVESTIGATIONS CONCERNED WITH THE EXPERIMENTAL TREATMENT OF HYPERTENSION WITH KIDNEY EXTRACTS(A PROGRESS REPORT OF INVESTIGATIONS CONCERNED WITH THE EXPERIMENTAL TREATMENT OF HYPERTENSION WITH KIDNEY EXTRACTS*). Ann Intern Med. 1943;18:29–42. doi: 10.7326/0003-4819-18-1-29
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Published: Ann Intern Med. 1943;18(1):29-42.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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