GUSTAV J. MARTIN; E. H. RENNEBAUM; MARVIN R. THOMPSON
Indole, histamine and guanidine are representative examples of toxic chemicals produced endogenously. These compounds were considered as a group not only because of their endogenous origin but also because each is associated with diseases known to afflict the human body. No study of therapeutic and prophylactic detoxication would be complete without a consideration of these toxic metabolites. It is to be emphasized that each is a representative of a group of toxic substances and that there is a large number of additional groups of toxic metabolites.
Histamine is formed through the action of putrefactive bacteria on histidine.1 It has
MARTIN GJ, RENNEBAUM EH, THOMPSON MR. PROPHYLACTIC AND THERAPEUTIC DETOXICATION: GUANIDINE, INDOLE AND HISTAMINE1. Ann Intern Med. 1943;18:57–71. doi: 10.7326/0003-4819-18-1-57
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Published: Ann Intern Med. 1943;18(1):57-71.
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