JOSEPH B. KIRSNER, M.D., Ph.D.; WALTER LINCOLN PALMER, M.D., Ph.D., F.A.C.P.
Although considerable emphasis has been placed on the development of alkalosis during the alkali treatment of peptic ulcer, this complication does not occur in most patients so treated. Recent studies1 have indicated that therapy may be continued for many years without significant alteration either in the acid base balance or in renal function. Berger,2 Jeghers and Lerner,3 and others occasionally have observed patients in whom the prolonged use of large quantities of sodium bicarbonate and calcium carbonate caused no apparent untoward effects. This remarkable tolerance to alkalis is particularly well illustrated by the following case in which the ingestion
KIRSNER JB, PALMER WL. STUDIES ON THE EFFECT OF MASSIVE QUANTITIES OF SODIUM BICARBONATE ON THE ACID BASE EQUILIBRIUM AND ON RENAL FUNCTION: REPORT OF A CASE WITH REMARKABLE TOLERANCE1. Ann Intern Med. ;18:100–104. doi: 10.7326/0003-4819-18-1-100
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Published: Ann Intern Med. 1943;18(1):100-104.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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