FRANCIS D. MURPHY, M.D., F.A.C.P.; WILBUR D. WOOD, M.D.
The sulfonamides in their relation to the kidney may play the rôle of the "double-edged sword." They may participate in curing acute glomerulonephritis, or pyelitis, or they may harm the kidneys. Renal damage is considered the most important of the serious complications of sulfonamide therapy. It may result either from obstruction caused by masses of sulfonamide crystals in the renal tubules or ureters, or from parenchymal changes due to the nephrotoxic action of these drugs. Many reports have been published regarding the mechanical blocking of the tubules, pelves and ureters, and the hematuria, oliguria, anuria and uremia which may follow
MURPHY FD, WOOD WD. ACUTE NEPHRITIS AND THE EFFECT OF SULFONAMIDES ON THE KIDNEYS1. Ann Intern Med. ;18:999–1005. doi: 10.7326/0003-4819-18-6-999
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Published: Ann Intern Med. 1943;18(6):999-1005.
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