PAUL S. RHOADS, M.D., F.A.C.P.; MELVIN L. AFREMOW, M.D.
In 1937 Healey1 reported that about 3 per cent of young adults being immunized against scarlet fever developed multiple joint pains as a reaction to one or more injections of the sterile filtrate of broth cultures of scarlet fever streptococci. She noted that the majority of persons who had this reaction gave a history of previous joint pains associated with rheumatic fever, or of streptococcus infections of the nose and throat. We had made similar observations. Healey showed that 74.6 per cent of a group of 63 such persons which she studied did not have joint pains when injected with
RHOADS PS, AFREMOW ML. THE SIGNIFICANCE OF JOINT PAINS CAUSED BY STERILE STREPTOCOCCUS TOXIN1. Ann Intern Med. ;19:60–63. doi: 10.7326/0003-4819-19-1-60
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Published: Ann Intern Med. 1943;19(1):60-63.
Infectious Disease, Streptococcal Infections.
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