The term influenza has been used customarily to indicate a clinical syndrome rather than a clear cut etiological entity. The usual clinical manifestations of "influenza" are familiar to all our readers: the abrupt onset with fever, malaise, prostration, generalized aches and pains, signs of irritation of the respiratory mucous membranes which are often slight in comparison with the systemic symptoms, a leukopenia and usually a high degree of contagiousness. Illness of this type may occur in great pandemics, as localized epidemics which may have a high morbidity within the area involved, and as sporadic interepidemic cases, commonly called "endemic influenza."
IMMUNITY FROM INFLUENZA AND POSSIBLE METHODS FOR ITS PRODUCTION. Ann Intern Med. ;19:163–167. doi: 10.7326/0003-4819-19-1-163
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Published: Ann Intern Med. 1943;19(1):163-167.
Infectious Disease, Influenza, Pulmonary/Critical Care.
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