RULON W. RAWSON; RUTH M. GRAHAM; CHARLOTTE B. RIDDELL
Many investigators1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 have demonstrated an impressive similarity between changes induced in laboratory animals treated with the thyroid stimulating hormone of the pituitary (TSH), and the clinical entity, Graves' disease. Such changes include hyperplasia of the thyroid, tachycardia, weight loss, increase in oxygen consumption, and exophthalmos. On the basis of such observations one might be tempted to conclude that the pituitary is a factor in the etiology of clinical thyrotoxicosis. However, one serious objection to such a conclusion is the fact that several investigators14, 15, 16, 17, 18
RAWSON RW, GRAHAM RM, RIDDELL CB. PHYSIOLOGICAL REACTIONS OF THE THYROID STIMULATING HORMONE OF THE PITUITARY. II. THE EFFECT OF NORMAL AND PATHOLOGICAL HUMAN THYROID TISSUES ON THE ACTIVITY OF THE THYROID STIMULATING HORMONE1. Ann Intern Med. ;19:405–414. doi: 10.7326/0003-4819-19-3-405
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Published: Ann Intern Med. 1943;19(3):405-414.
Endocrine and Metabolism, Neurology, Pituitary Disorders, Thyroid Disorders.
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