Although the pathway of infection in poliomyelitis has long been a matter of controversy, until recently it was generally believed to be usually the nasal olfactory mucosa, the olfactory tracts and bulbs, from which the virus spreads by direct extension to the motor areas of the brain and spinal cord. Infection was thought to be acquired by droplet infection or direct contact, usually from carriers or unrecognized subclinical cases of the disease. This view has been maintained by Flexner and his associates, based largely on their studies of experimental infections in monkeys.
More recent work, however, has cast doubt on
EXTRA-HUMAN SOURCES OF POLIOMYELITIS VIRUS. Ann Intern Med. ;19:549–551. doi: 10.7326/0003-4819-19-3-549
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Published: Ann Intern Med. 1943;19(3):549-551.
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