MAUD L. MENTEN, M.D., PH.D., F.A.C.P.; MARIE A. ANDERSCH, PH.D.
The introduction of the sulfonamides into chemotherapy undoubtedly has reduced appreciably the mortality rate of many infections. However, certain untoward effects were not unexpected because of the inherent toxicity of these drugs and because of individual idiosyncrasy. A number of clinical reports have appeared regarding the deleterious effects of the sulfonamides on the hematopoietic system and the urinary tract. Toxic effects on the liver, as indicated by the development of jaundice, have been of less frequent occurrence. Varying degrees of pathologic change have been found by us in the liver of several infants and children dying during the course of
MENTEN ML, ANDERSCH MA. HEPATIC DAMAGE ASSOCIATED WITH SULFONAMIDE THERAPY IN INFANTS AND CHILDREN. I. MORPHOLOGIC PATHOLOGY1. Ann Intern Med. ;19:609–621. doi: 10.7326/0003-4819-19-4-609
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Published: Ann Intern Med. 1943;19(4):609-621.
Gastroenterology/Hepatology, Liver Disease.
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