MARIE A. ANDERSCH, PH.D.
Sulfonamides have proved effective in the treatment of many infections, and in only a few instances have there been reports of clinical signs of liver dysfunction. This, however, may occasionally occur. The evidence offered in the previous paper of liver disease at times associated with sulfonamide therapy in children led to an investigation of the possibility of the early detection of hepatic damage during treatment. Liver function tests based on alteration of plasma globulin appear to be exceedingly sensitive, and with the use of one of these tests it has been possible to detect changes in liver which occurred during
ANDERSCH MA. HEPATIC DAMAGE ASSOCIATED WITH SULFONAMIDE THERAPY IN INFANTS AND CHILDREN. II. CHANGES IN LIVER FUNCTION TEST DURING SULFONAMIDE THERAPY1. Ann Intern Med. ;19:622–628. doi: 10.7326/0003-4819-19-4-622
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Published: Ann Intern Med. 1943;19(4):622-628.
Gastroenterology/Hepatology, Liver Disease.
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