DAVID ADLERSBERG, M.D.; CHARLES L. FOX JR., M.D.
It has long been recognized that liver diseases are frequently associated with disturbances in water metabolism. Hanot made the well known statement "Il y a un oedème hépatique comme il y a un oedème renal." Gilbert and Lereboullet1 observed in some cases of liver disease oliguria, "opsiurie hépatique," which in severe cases may lead to anuria. Later, experimental observations, particularly by E. P. Pick and his coworkers,2 established the important rôle of the liver in water metabolism. Analogous clinical observations have also been made.3 It seemed that the disturbance of water metabolism would be of diagnostic significance if it could
ADLERSBERG D, FOX CL. CHANGES OF THE WATER TOLERANCE TEST IN HEPATIC DISEASE1. Ann Intern Med. 1943;19:642–650. doi: 10.7326/0003-4819-19-4-642
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Published: Ann Intern Med. 1943;19(4):642-650.
Gastroenterology/Hepatology, Liver Disease.
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