Many instances are known in which the presence and growth of one microörganism is antagonistic to the growth and multiplication of another species. One of the best examples of this action became known through the observation of Fleming1 that colonies of a certain species of mould (Penicillium notatum) inhibited the growth of colonies of many species of bacteria in their vicinity. He showed that the inhibiting substance, which he named penicillin, was present in broth culture filtrates of the organism. He demonstrated that its action was selective and limited largely to Gram-positive organisms, particularly the pyogenic cocci. On the other
ANTIBIOTIC SUBSTANCES PRODUCED BY MICROÖRGANISMS. Ann Intern Med. ;19:691–694. doi: 10.7326/0003-4819-19-4-691
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Published: Ann Intern Med. 1943;19(4):691-694.
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