MARTIN H. DAWSON; GLADYS L. HOBBY; KARL MEYER; ELEANOR CHAFFEE
In 1929, while examining plates seeded with staphylococci, Fleming1 observed that colonies failed to grow in the neighborhood of a colony of a contaminating mold. Following up this chance observation, Fleming isolated the mold, identified it as a strain of Penicillium notatum, and showed that it produced in broth cultures a soluble substance which exerted a remarkable inhibitory effect on pyogenic cocci and the diphtheria group of organisms but not on certain Gram negative rods. He designated the substance as penicillin and suggested that it might be used for differential diagnostic purposes in the cultivation of Gram positive and Gram
DAWSON MH, HOBBY GL, MEYER K, CHAFFEE E. PENICILLIN AS A CHEMOTHERAPEUTIC AGENT1. Ann Intern Med. 1943;19:707–717. doi: 10.7326/0003-4819-19-5-707
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Published: Ann Intern Med. 1943;19(5):707-717.
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