RULON W. RAWSON; S. HERTZ; J. H. MEANS, F.A.C.P.
That a definite relationship exists between iodine deficiency and many non-toxic goiters is well established. Indeed endemic goiter is usually, and perhaps too readily, accepted as being due to iodine deficiency. Experimentally, thyroid hyperplasia has been produced in various laboratory animals by many goitrogenic agents other than iodine deficient diets. Astwood, et al.1 in a recent report, referred to extensive literature on a variety of goitrogens.
Some of the most interesting studies in goitrogenesis were incited by observations made by Chesney, Clawson and Webster2, 3, 4 in 1928. They observed large hyperplastic goiters in rabbits maintained on cabbage diets. In
RAWSON RW, HERTZ S, MEANS JH. THIOCYANATE GOITER IN MAN1. Ann Intern Med. ;19:829–842. doi: 10.7326/0003-4819-19-6-829
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Published: Ann Intern Med. 1943;19(6):829-842.
Endocrine and Metabolism, Thyroid Disorders.
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