EUGENE P. CRONKITE, M.D.
Troland and Lee, in 1938,1, 2 reported that acetone extracts of spleens from patients with "idiopathic" thrombopenic purpura produced a marked transient lowering of platelets when injected into rabbits. Some subsequent workers confirmed these results; others were unable to reproduce them.3, 4 Rose and Boyer,5 however, reported in 1940 from this clinic definite platelet lowering effects of spleen extracts from purpura cases and concluded that the results of Troland and Lee must be accepted. In 1940 Paul6 again reviewed the literature and made further experiments demonstrating a platelet depressing substance.
The present report deals with further studies of the effect
CRONKITE EP. FURTHER STUDIES OF PLATELET REDUCING SUBSTANCES IN SPLENIC EXTRACTS1. Ann Intern Med. 1944;20:52–62. doi: 10.7326/0003-4819-20-1-52
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Published: Ann Intern Med. 1944;20(1):52-62.
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