ROBERT LEROY HUTTON, M.D., F.A.C.P.; CHESTER R. BROWN, M.D.
Since Rayer1 emphasized the nephritic complications of rheumatic fever there have been numerous observations, all of which note the infrequency of clinical evidence of renal involvement during the active stages of this disease. In a large series of cases the incidence of nephritic complications varies between 0.67 and 7 per cent.2, 3, 4, 5, 6, 7, 8, 9, 10 Despite this, Bell11 finds cardiac rheumatism and nephritis to be frequent in necropsy material. In necropsies of 104 cases of rheumatic valvulitis showing active lesions, he found renal involvement in 24.9 per cent, 22 per cent of which showed acute diffuse
HUTTON RL, BROWN CR. THE RENAL LESION IN RHEUMATIC FEVER1. Ann Intern Med. ;20:85–98. doi: 10.7326/0003-4819-20-1-85
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Published: Ann Intern Med. 1944;20(1):85-98.
Infectious Disease, Nephrology, Rheumatology, Streptococcal Infections.
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