WALTER MODELL, M.D.
Fatalities following the injection of mercupurin,1 a phenomenon rarely reported in cardiac patients, stimulated interest in the problem of the safest effective dose of the mercurial diuretics. It has been suggested2 that doses much larger than necessary are used, occasionally to the detriment of the patient. In New and Nonofficial Remedies,3 the doses of merbaphen, mercupurin and salyrgan-theophyllin (each containing about 35 to 40 mg. of mercury per c.c.) are given as from 1 to 2 c.c. In Goodman and Gilman's textbook,4 the same doses are advised. Similarly, Fishberg,5 Levine,6 and White7 suggest doses of from 1 to 2 c.c.
MODELL W. THE OPTIMAL DOSE OF MERCURIAL DIURETICS1. Ann Intern Med. ;20:265–274. doi: 10.7326/0003-4819-20-2-265
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Published: Ann Intern Med. 1944;20(2):265-274.
Cardiology, Hospital Medicine.
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