BERNARD MAISEL; CHARLES S. KUBIK; JAMES B. AYER
Current medical literature contains many papers dealing directly or indirectly with the toxic effects of the sulfonamides. As death is not the usual outcome of such cases, autopsies are not numerous and, therefore, the pathological manifestations are as yet not fully recognized.
Clinical evidence indicates that the kidneys may be affected by these drugs, and in those patients who succumb, marked changes in the kidneys have been demonstrated. In these cases the pathological physiology is uncertain and has usually been attributed to renal obstruction consequent to the precipitation of the less soluble forms of the sulfonamides. The case reported
MAISEL B, KUBIK CS, AYER JB. ENCEPHALOPATHY, NEPHROSIS, AND RENAL GRANULOMA FOLLOWING SULFONAMIDE THERAPY; CASE WITH AUTOPSY1. Ann Intern Med. 1944;20:311–326. doi: 10.7326/0003-4819-20-2-311
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Published: Ann Intern Med. 1944;20(2):311-326.
Encephalopathy, Nephrology, Nephrotic Syndrome, Neurology.
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