D. ROURKE GILLIGAN; JAMES A. DINGWALL 3D; WALSH MCDERMOTT
Recent studies in this hospital1 and in other clinics2 have demonstrated the effectiveness of adjuvant alkali therapy in preventing renal complications from sulfadiazine. This protective action is attributable to the fact that alkalinization of the urine increases the solubility of sulfadiazine and its N4-acetyl derivative1, 3, 4 and thereby prevents their precipitation in the kidneys and urinary tract.
The optimal dosage and mode of administration of alkali during oral therapy with sulfadiazine have been studied in a large series of patients.1 Alkalinization of the urine during parenteral therapy with sodium sulfadiazine presents a special problem which is the subject of
GILLIGAN DR, DINGWALL JA, MCDERMOTT W. THE PARENTERAL USE OF SODIUM LACTATE SOLUTION IN THE PREVENTION OF RENAL COMPLICATIONS FROM PARENTERALLY ADMINISTERED SODIUM SULFADIAZINE1. Ann Intern Med. 1944;20:604–618. doi: 10.7326/0003-4819-20-4-604
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Published: Ann Intern Med. 1944;20(4):604-618.
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