ALLAN T. KENYON; KATHRYN KNOWLTON; IRENE SANDIFORD
In 1889 Brown-Sequard,1 then 72 years old, injected a testicular extract into himself and felt a return of his youthful sense of well-being. Little substance remains from this early experiment in human organotherapy although historians speak of an impetus given thereby to endocrine research. Such extracts of the testis are inactive in simple objective tests, and the subjective and probably imaginative character of Brown-Sequard's response never inspired much confidence in his interpretation of testicular function. Nevertheless the very prominence of this experiment in the history of endocrinology has served to keep alive Brown-Sequard's guiding thought that the testis might exert
KENYON AT, KNOWLTON K, SANDIFORD I. THE ANABOLIC EFFECTS OF THE ANDROGENS AND SOMATIC GROWTH IN MAN1. Ann Intern Med. 1944;20:632–654. doi: 10.7326/0003-4819-20-4-632
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Published: Ann Intern Med. 1944;20(4):632-654.
Endocrine and Metabolism.
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