CARL F. SHAFFER, M.D.
Arteriosclerosis, exclusive of the infectious diseases of the arterial system, may be divided pathologically into three types: (1) Atherosclerosis, associated with diseases of the aorta and coronary arteries; (2) arteriolar (or diffuse), sclerosis, associated with arterial hypertension; and (3) Mönckeberg's sclerosis, not clinically significant unless there is superimposed atherosclerosis.
Etiology. Hueper, in a review of the etiology of arteriosclerosis, has concluded that the fundamental causal mechanism is an impairment of nutrition and oxygenation of the artery, resulting in damage to the endothelium, increased permeability of the intima, and infiltration of the plasma into the subintimal tissue with later proliferation of
SHAFFER CF. THE NUTRITIONAL RÔLE OF CHOLESTEROL IN HUMAN CORONARY ARTERIOSCLEROSIS1. Ann Intern Med. 1944;20:948–953. doi: 10.7326/0003-4819-20-6-948
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Published: Ann Intern Med. 1944;20(6):948-953.
Cardiology, Coronary Heart Disease.
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