GORDON I. TREVETT, M.D.; S. S. BLACKMAN JR., M.D.
It is known that sulfonamide drug therapy may be complicated by the precipitation of crystals or the formation of concretions in the urinary tract. Considerable evidence has been presented indicating that these crystals may be responsible for the anuria, azotemia and hematuria encountered during sulfonamide therapy. The possibility that these drugs may induce hematuria through some toxic action on the glomeruli has not been excluded.
It seemed advisable to determine the source of hematuria in experimental animals and to establish the relative frequency of these two potential sources. At autopsy glomerular bleeding would be indicated by the presence of red
TREVETT GI, BLACKMAN SS. THE SOURCE OF SULFATHIAZOLE HEMATURIA INDUCED IN RABBITS.1. Ann Intern Med. 1944;20:971–980. doi: 10.7326/0003-4819-20-6-971
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Published: Ann Intern Med. 1944;20(6):971-980.
Nephrology, Urological Disorders.
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