STUART W. COSGRIFF, M.D.
With the recent increase in prevalence of meningococcal meningitis, there has been, as might be anticipated, an associated rise in the number of cases of the so-called Waterhouse-Friderichsen syndrome.1, 2 This condition, characterized by shock, purpura and hemorrhages into the adrenal glands, is encountered in overwhelming sepsis resulting as a rule from meningococcus infection, but it may also be due to any one of a variety of organisms.3, 4, 5 Because this symptom complex has been described infrequently in the past, it becomes of interest to review this disorder with particular emphasis on possible relationships of adrenal insufficiency to
COSGRIFF SW. THE WATERHOUSE-FRIDERICHSEN SYNDROME: OBERVATIONS ON ASSOCIATED ADRENAL INSUFFICIENCY AND REPORT OF FOUR CASES(THE WATERHOUSE-FRIDERICHSEN SYNDROME: OBERVATIONS ON ASSOCIATED ADRENAL INSUFFICIENCY AND REPORT OF FOUR CASES*). Ann Intern Med. 1944;21:187–193. doi: 10.7326/0003-4819-21-2-187
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Published: Ann Intern Med. 1944;21(2):187-193.
Adrenal Disorders, CNS Infections, Endocrine and Metabolism, Infectious Disease, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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