FRANK S. PERKIN, M.D., F.A.C.P.
The rôle of syphilis in the etiology of diabetes mellitus has long been a subject of controversy. Isolated cases of the association of the two diseases have appeared in the literature since 1889; some reported apparent improvement in the diabetes following antisyphilitic treatment, whereas others noted a loss of carbohydrate tolerance. The majority of the reports have appeared in the foreign literature where the subject has aroused more interest.
These cases were all subject to the just criticisms that they had not been properly studied from a diabetic standpoint, they had not been observed for an adequate period, and were
PERKIN FS. SYPHILIS AND DIABETES MELLITUS; A LONGTERM CLINICAL STUDY1. Ann Intern Med. ;21:272–284. doi: 10.7326/0003-4819-21-2-272
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Published: Ann Intern Med. 1944;21(2):272-284.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Infectious Disease.
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