EDMUND L. SHLEVIN, M.D.; MAX LEDERER, M.D.
Interest in anti-coagulants as therapeutic agents has encouraged the trial of various substances in conditions characterized by intravascular clotting with resultant thrombosis and embolism. During the past few years heparin has occupied a leading rôle in this respect, until the discovery of the part played by spoiled sweet clover in the production of hemorrhagic disease of cattle.1 The recognition of the active principal, dicoumarin (3,3′ Methylenebis [4-Hydroxycoumarin]), its isolation and synthesis by Link and his coworkers,2 have paved the way for its therapeutic employment in man.
Most reports thus far in the literature have described the beneficial results from its
SHLEVIN EL, LEDERER M. UNCONTROLLABLE HEMORRHAGE AFTER DICOUMAROL THERAPY WITH AUTOPSY FINDINGS1. Ann Intern Med. ;21:332–342. doi: 10.7326/0003-4819-21-2-332
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Published: Ann Intern Med. 1944;21(2):332-342.
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