Infection with the yeast-like organism histoplasma was first reported in 1906 by Darling, who discovered three cases of the infection in the course of a systematic search for kala azar in the Canal Zone. Clinically the disease in Darling's1 cases was "characterized by splenomegaly, emaciation, irregular pyrexia, leukopenia and anemia." The pathologic lesions he described as "the invasion of endothelial cells in the smaller lymph and blood vessels and capillaries by enormous numbers of a small encapsulated organism (Histoplasma capsulatum) causing necrosis of the liver with cirrhosis, splenomegaly, pseudogranuloma of the lungs, small and large intestines with ulceration of the
HISTOPLASMOSIS. Ann Intern Med. ;21:343–346. doi: 10.7326/0003-4819-21-2-343
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Published: Ann Intern Med. 1944;21(2):343-346.
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