EDMUND JACOBSON, PH.D., M.D., F.A.C.P.
Many publications appear each year concerning the influence of stimulants and sedatives in animals and in man. Investigations have afforded much indirect evidence of the action of such agents on the nervous and muscular systems. However, direct quantitative measurements of functional states in the intact organism following the administration of pharmacological substances have never been attempted, doubtless because of lack of suitable instruments. The possibility of such investigation has finally been opened by advances in electrophysiology in the last decade. Most convenient for the present investigation, which I believe marks a first step in this special field, is apparatus capable
JACOBSON E. DIRECT MEASUREMENTS OF THE EFFECTS OF BROMIDES, SODIUM AMYTAL AND OF CAFFEINE IN MAN1. Ann Intern Med. ;21:455–468. doi: 10.7326/0003-4819-21-3-455
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Published: Ann Intern Med. 1944;21(3):455-468.
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